ExplorEnz: EC 1.1.1.376

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1.1.1.376

Accepted name:

L-arabinose 1-dehydrogenase [NAD(P)⁺]

Reaction:

α-L-arabinopyranose + NAD(P)⁺ = L-arabinono-1,4-lactone + NAD(P)H + H⁺

For diagram of L-Arabinose catabolism, click here

Other name(s):

L-arabino-aldose dehydrogenase

Systematic name:

α-L-arabinopyranose:NAD(P)⁺ 1-oxidoreductase

Comments:

The enzymes from the bacterium Azospirillum brasilense and the archaeon Haloferax volcanii are part of the L-arabinose degradation pathway and prefer NADP⁺ over NAD⁺. In vitro the enzyme from Azospirillum brasilense shows also high catalytic efficiency with D-galactose. The enzyme is specific for α-L-arabinopyranose [3,4].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Novick, N.J. and Tyler, M.E. Partial purification and properties of an L-arabinose dehydrogenase from Azospirillum brasilense. Can. J. Microbiol. 29 (1983) 242–246.
2.	Watanabe, S., Kodaki, T. and Makino, K. Cloning, expression, and characterization of bacterial L-arabinose 1-dehydrogenase involved in an alternative pathway of L-arabinose metabolism. J. Biol. Chem. 281 (2006) 2612–2623. [DOI] [PMID: 16326697]
3.	Johnsen, U., Sutter, J.M., Zaiss, H. and Schonheit, P. L-Arabinose degradation pathway in the haloarchaeon Haloferax volcanii involves a novel type of L-arabinose dehydrogenase. Extremophiles 17 (2013) 897–909. [DOI] [PMID: 23949136]
4.	Aro-Karkkainen, N., Toivari, M., Maaheimo, H., Ylilauri, M., Pentikainen, O.T., Andberg, M., Oja, M., Penttila, M., Wiebe, M.G., Ruohonen, L. and Koivula, A. L-arabinose/D-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of L-arabinose to L-arabonate with Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 98 (2014) 9653–9665. [DOI] [PMID: 25236800]

[EC 1.1.1.376 created 2014, modified 2022]