The Enzyme Database

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EC 1.1.1.349     
Accepted name: norsolorinic acid ketoreductase
Reaction: (1′S)-averantin + NADP+ = norsolorinic acid + NADPH + H+
Glossary: norsolorinic acid = 2-hexanoyl-1,3,6,8-tetrahydroxy-9,10-anthraquinone
(1′S)-averantin = 1,3,6,8-tetrahydroxy-[(1S)-2-hydroxyhexyl]-9,10-anthraquinone
Other name(s): aflD (gene name); nor-1 (gene name)
Systematic name: (1′S)-averantin:NADP+ oxidoreductase
Comments: Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Yabe, K., Matsuyama, Y., Ando, Y., Nakajima, H. and Hamasaki, T. Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin. Appl. Environ. Microbiol. 59 (1993) 2486–2492. [PMID: 8368836]
2.  Zhou, R. and Linz, J.E. Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus. Appl. Environ. Microbiol. 65 (1999) 5639–5641. [PMID: 10584035]
[EC 1.1.1.349 created 2013]
 
 


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