ExplorEnz: EC 1.1.1.332

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1.1.1.332

Accepted name:

chanoclavine-I dehydrogenase

Reaction:

chanoclavine-I + NAD⁺ = chanoclavine-I aldehyde + NADH + H⁺

Glossary:

chanoclavine-I = (1E)-2-methyl-3-[(4R,5R)-4-(methylamino)-1,3,4,5-tetrahydrobenz[cd]indol-5-yl]prop-2-en-1-ol
chanoclavine-I aldehyde = (1E)-2-methyl-3-[(4R,5R)-4-(methylamino)-1,3,4,5-tetrahydrobenz[cd]indol-5-yl]prop-2-enal

Other name(s):

easD (gene name); fgaDH (gene name)

Systematic name:

chanoclavine-I:NAD⁺ oxidoreductase

Comments:

The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Wallwey, C., Matuschek, M. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH. Arch. Microbiol. 192 (2010) 127–134. [DOI] [PMID: 20039019]
2.	Wallwey, C., Heddergott, C., Xie, X., Brakhage, A.A. and Li, S.M. Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae. Microbiology 158 (2012) 1634–1644. [DOI] [PMID: 22403186]

[EC 1.1.1.332 created 2012]