EC |
1.1.1.302 |
Accepted name: |
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5′-phosphate reductase |
Reaction: |
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+
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For diagram of riboflavin biosynthesis (early stages), click here |
Other name(s): |
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5′-phosphate reductase; MjaRED; MJ0671 (gene name) |
Systematic name: |
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase |
Comments: |
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5′-phosphate [1]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Graupner, M., Xu, H. and White, R.H. The pyrimidine nucleotide reductase step in riboflavin and F420 biosynthesis in archaea proceeds by the eukaryotic route to riboflavin. J. Bacteriol. 184 (2002) 1952–1957. [DOI] [PMID: 11889103] |
2. |
Chatwell, L., Krojer, T., Fidler, A., Romisch, W., Eisenreich, W., Bacher, A., Huber, R. and Fischer, M. Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5′-phosphate reductase of Methanocaldococcus jannaschii. J. Mol. Biol. 359 (2006) 1334–1351. [DOI] [PMID: 16730025] |
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[EC 1.1.1.302 created 2010, modified 2011] |
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