EC |
1.1.1.291 |
Accepted name: |
2-hydroxymethylglutarate dehydrogenase |
Reaction: |
(S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+ |
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For diagram of nicotinate catabolism, click here |
Other name(s): |
HgD |
Systematic name: |
(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase |
Comments: |
NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Δ-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 1073478-76-8 |
References: |
1. |
Alhapel, A., Darley, D.J., Wagener, N., Eckel, E., Elsner, N. and Pierik, A.J. Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri. Proc. Natl. Acad. Sci. USA 103 (2006) 12341–12346. [DOI] [PMID: 16894175] |
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[EC 1.1.1.291 created 2006] |
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