ExplorEnz: EC 1.1.1.289

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1.1.1.289

Accepted name:

sorbose reductase

Reaction:

D-glucitol + NADP⁺ = L-sorbose + NADPH + H⁺

For diagram of reaction, click here

Glossary:

L-sorbose = L-xylo-hex-2-ulose

Other name(s):

Sou1p

Systematic name:

D-glucitol:NADP⁺ oxidoreductase

Comments:

The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 138440-90-1

References:

1.	Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E. Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization. Yeast 22 (2005) 957–969. [DOI] [PMID: 16134116]
2.	Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E. Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization. Yeast 22 (2005) 1171.
3.	Sugisawa, T., Hoshino, T. and Fujiwara, A. Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1. Agric. Biol. Chem. 55 (1991) 2043–2049.
4.	Shinjoh, M., Tazoe, M. and Hoshino, T. NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291. J. Bacteriol. 184 (2002) 861–863. [DOI] [PMID: 11790761]

[EC 1.1.1.289 created 2006]