Accepted name: 2-(S)-hydroxypropyl-CoM dehydrogenase
Reaction: (2S)-2-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+
Glossary: coenzyme M (CoM) = 2-mercaptoethanesulfonate
Other name(s): 2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase; 2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase
Systematic name: 2-{[(2S)-2-hydroxypropyl]sulfanyl}ethanesulfonate:NAD+ oxidoreductase
Comments: The enzyme is highly specific for (2S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC, 2-(R)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (R)-enantiomer. This enzyme forms component IV of a four-component enzyme system click here that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
1.  Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A. A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation. Proc. Natl. Acad. Sci. USA 96 (1999) 8432–8437. [PMID: 10411892]
[EC created 2001]

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