The enzyme is highly specific for (2S)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 220.127.116.118, 2-(R)-hydroxypropyl-CoM dehydrogenase, which is highly specific for the (R)-enantiomer. This enzyme forms component IV of a four-component enzyme system EC 18.104.22.168 (2-hydroxypropyl-CoM lyase; component I), EC 22.214.171.124 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 126.96.36.1998 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 188.8.131.529 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV].html">click here that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A. A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation. Proc. Natl. Acad. Sci. USA96 (1999) 8432–8437. [DOI] [PMID: 10411892]