Accepted name: tetrahydroxynaphthalene reductase
Reaction: scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
Systematic name: scytalone:NADP+ Δ5-oxidoreductase
Comments: Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.
1.  Wheeler, M.H. and Greenblatt, G.A. The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease. Exp. Mycol. 12 (1988) 151–160.
2.  Vidal-Cros, A., Viviani, F., Labesse, G., Boccara, M. and Gaudry, M. Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing. Eur. J. Biochem. 219 (1994) 985–992. [PMID: 8112349]
3.  Thompson, J.E., Basarab, G.S., Andersson, A., Lindqvist, Y. and Jordan, D.B. Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism. Biochemistry 36 (1997) 1852–1860. [PMID: 9048570]
[EC created 1992 as EC, transferred 1999 to EC]

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