The Enzyme Database

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EC 1.1.1.23     
Accepted name: histidinol dehydrogenase
Reaction: L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+
Other name(s): L-histidinol dehydrogenase
Systematic name: L-histidinol:NAD+ oxidoreductase
Comments: Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC 3.6.1.31 (phosphoribosyl-ATP diphosphatase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-27-7
References:
1.  Adams, E. Enzymatic synthesis of histidine from histidinol. J. Biol. Chem. 209 (1954) 829–846. [PMID: 13192138]
2.  Adams, E. L-Histidinal, a biosynthetic precursor of histidine. J. Biol. Chem. 217 (1955) 325–344. [PMID: 13271397]
3.  Loper, J.C. Histidinol dehydrogenase from Salmonella typhimurium. Crystallization and composition studies. J. Biol. Chem. 243 (1968) 3264–3272. [PMID: 4872177]
4.  Yourno, J. and Ino, I. Purification and crystallization of histidinol dehydrogenase from Salmonella typhimurium LT-2. J. Biol. Chem. 243 (1968) 3273–3276. [PMID: 4872176]
[EC 1.1.1.23 created 1961]
 
 


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