The Enzyme Database

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EC 1.1.1.146     
Accepted name: 11β-hydroxysteroid dehydrogenase
Reaction: an 11β-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
Other name(s): corticosteroid 11β-dehydrogenase; β-hydroxysteroid dehydrogenase; 11β-hydroxy steroid dehydrogenase; corticosteroid 11-reductase; dehydrogenase, 11β-hydroxy steroid
Systematic name: 11β-hydroxysteroid:NADP+ 11-oxidoreductase
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9041-46-7
References:
1.  Agarwal, A.K., Monder, C., Eckstein, B. and White, P.C. Cloning and expression of rat cDNA encoding corticosteroid 11β-dehydrogenase. J. Biol. Chem. 264 (1989) 18939–18943. [PMID: 2808402]
2.  Bush, I.E., Hunter, S.A. and Meigs, R.A. Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver. Biochem. J. 107 (1968) 239–258. [PMID: 4384445]
3.  Lakshmi, V. and Monder, C. Purification and characterization of the corticosteroid 11β-dehydrogenase component of the rat liver 11β-hydroxysteroid dehydrogenase complex. Endocrinology 123 (1988) 2390–2398. [PMID: 3139396]
4.  Phillips, D.M., Lakshmi, V. and Monder, C. Corticosteroid 11β-dehydrogenase in rat testis. Endocrinology 125 (1989) 209–216. [PMID: 2661206]
[EC 1.1.1.146 created 1972]
 
 


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