| |
| 1. | Oxidoreductases |
| | 1.1 | Acting on the CH-OH group of donors |
| | | 1.1.1 | With NAD+ or NADP+ as acceptor |
| | | 1.1.2 | With a cytochrome as acceptor |
| | | 1.1.3 | With oxygen as acceptor |
| | | 1.1.4 | With a disulfide as acceptor |
| | | 1.1.5 | With a quinone or similar compound as acceptor |
| | | 1.1.99 | With other acceptors |
| | 1.2 | Acting on the aldehyde or oxo group of donors |
| | | 1.2.1 | With NAD+ or NADP+ as acceptor |
| | | 1.2.2 | With a cytochrome as acceptor |
| | | 1.2.3 | With oxygen as acceptor |
| | | 1.2.4 | With a disulfide as acceptor |
| | | 1.2.7 | With an iron-sulfur protein as acceptor |
| | | 1.2.99 | With other acceptors |
| | 1.3 | Acting on the CH-CH group of donors |
| | | 1.3.1 | With NAD+ or NADP+ as acceptor |
| | | 1.3.2 | With a cytochrome as acceptor |
| | | 1.3.3 | With oxygen as acceptor |
| | | 1.3.5 | With a quinone or related compound as acceptor |
| | | 1.3.7 | With an iron-sulfur protein as acceptor |
| | | 1.3.99 | With other acceptors |
| | 1.4 | Acting on the CH-NH2 group of donors |
| | | 1.4.1 | With NAD+ or NADP+ as acceptor |
| | | 1.4.2 | With a cytochrome as acceptor |
| | | 1.4.3 | With oxygen as acceptor |
| | | 1.4.4 | With a disulfide as acceptor |
| | | 1.4.7 | With an iron-sulfur protein as acceptor |
| | | 1.4.99 | With other acceptors |
| | 1.5 | Acting on the CH-NH group of donors |
| | | 1.5.1 | With NAD+ or NADP+ as acceptor |
| | | 1.5.3 | With oxygen as acceptor |
| | | 1.5.4 | With a disulfide as acceptor |
| | | 1.5.5 | With a quinone or similar compound as acceptor |
| | | 1.5.7 | With an iron-sulfur protein as acceptor |
| | | 1.5.8 | With a flavin as acceptor |
| | | 1.5.99 | With other acceptors |
| | 1.6 | Acting on NADH or NADPH |
| | | 1.6.1 | With NAD+ or NADP+ as acceptor |
| | | 1.6.2 | With a heme protein as acceptor |
| | | 1.6.3 | With oxygen as acceptor |
| | | 1.6.4 | With a disulfide as acceptor (deleted sub-subclass) |
| | | 1.6.5 | With a quinone or similar compound as acceptor |
| | | 1.6.6 | With a nitrogenous group as acceptor |
| | | 1.6.7 | With an iron-sulfur protein as acceptor (deleted sub-subclass) |
| | | 1.6.8 | With a flavin as acceptor (deleted sub-subclass) |
| | | 1.6.99 | With other acceptors |
| | 1.7 | Acting on other nitrogenous compounds as donors |
| | | 1.7.1 | With NAD+ or NADP+ as acceptor |
| | | 1.7.2 | With a cytochrome as acceptor |
| | | 1.7.3 | With oxygen as acceptor |
| | | 1.7.7 | With an iron-sulfur protein as acceptor |
| | | 1.7.99 | With other acceptors |
| | 1.8 | Acting on a sulfur group of donors |
| | | 1.8.1 | With NAD+ or NADP+ as acceptor |
| | | 1.8.2 | With a cytochrome as acceptor |
| | | 1.8.3 | With oxygen as acceptor |
| | | 1.8.4 | With a disulfide as acceptor |
| | | 1.8.5 | With a quinone or similar compound as acceptor |
| | | 1.8.6 | With a nitrogenous group as acceptor (deleted sub-subclass) |
| | | 1.8.7 | With an iron-sulfur protein as acceptor |
| | | 1.8.98 | With other, known, acceptors |
| | | 1.8.99 | With other acceptors |
| | 1.9 | Acting on a heme group of donors |
| | | 1.9.3 | With oxygen as acceptor |
| | | 1.9.6 | With a nitrogenous group as acceptor |
| | | 1.9.99 | With other acceptors |
| | 1.10 | Acting on diphenols and related substances as donors |
| | | 1.10.1 | With NAD+ or NADP+ as acceptor |
| | | 1.10.2 | With a cytochrome as acceptor |
| | | 1.10.3 | With oxygen as acceptor |
| | | 1.10.99 | With other acceptors |
| | 1.11 | Acting on a peroxide as acceptor |
| | | 1.11.1 | Peroxidases |
| | 1.12 | Acting on hydrogen as donor |
| | | 1.12.1 | With NAD+ or NADP+ as acceptor |
| | | 1.12.2 | With a cytochrome as acceptor |
| | | 1.12.5 | With a quinone or similar compound as acceptor |
| | | 1.12.7 | With an iron-sulfur protein as acceptor |
| | | 1.12.98 | With other, known, acceptors |
| | | 1.12.99 | With other acceptors |
| | 1.13 | Acting on single donors with O2 as oxidant and incorporation of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2 |
| | | 1.13.11 | With incorporation of two atoms of oxygen |
| | | 1.13.12 | With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases) |
| | | 1.13.99 | Miscellaneous |
| | 1.14 | Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 |
| | | 1.14.1 | With NADH or NADPH as one donor (deleted sub-subclass) |
| | | 1.14.2 | With ascorbate as one donor (deleted sub-subclass) |
| | | 1.14.3 | With reduced pteridine as one donor (deleted sub-subclass) |
| | | 1.14.11 | With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| | | 1.14.12 | With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| | | 1.14.13 | With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| | | 1.14.14 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor |
| | | 1.14.15 | With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor |
| | | 1.14.16 | With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor |
| | | 1.14.17 | With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor |
| | | 1.14.18 | With another compound as one donor, and incorporation of one atom of oxygen into the other donor |
| | | 1.14.19 | With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water |
| | | 1.14.20 | With 2-oxoglutarate as one donor, and the other dehydrogenated |
| | | 1.14.21 | With NADH or NADPH as one donor, and the other dehydrogenated |
| | | 1.14.99 | Miscellaneous |
| | 1.15 | Acting on superoxide as acceptor |
| | | 1.15.1 | Acting on superoxide as acceptor (only sub-subclass identified to date) |
| | 1.16 | Oxidizing metal ions |
| | | 1.16.1 | With NAD+ or NADP+ as acceptor |
| | | 1.16.3 | With oxygen as acceptor |
| | | 1.16.8 | With a flavin as acceptor |
| | 1.17 | Acting on CH or CH2 groups |
| | | 1.17.1 | With NAD+ or NADP+ as acceptor |
| | | 1.17.3 | With oxygen as acceptor |
| | | 1.17.4 | With a disulfide as acceptor |
| | | 1.17.5 | With a quinone or similar compound as acceptor |
| | | 1.17.99 | With other acceptors |
| | 1.18 | Acting on iron-sulfur proteins as donors |
| | | 1.18.1 | With NAD+ or NADP+ as acceptor |
| | | 1.18.2 | With dinitrogen as acceptor (deleted sub-subclass) |
| | | 1.18.3 | With H+ as acceptor (deleted sub-subclass) |
| | | 1.18.6 | With dinitrogen as acceptor |
| | | 1.18.96 | With other, known, acceptors (deleted sub-subclass) |
| | | 1.18.99 | With H+ as acceptor (deleted sub-subclass) |
| | 1.19 | Acting on reduced flavodoxin as donor |
| | | 1.19.6 | With dinitrogen as acceptor |
| | 1.20 | Acting on phosphorus or arsenic in donors |
| | | 1.20.1 | With NAD+ or NADP+ as acceptor |
| | | 1.20.4 | With disulfide as acceptor |
| | | 1.20.98 | With other, known, acceptors |
| | | 1.20.99 | With other acceptors |
| | 1.21 | Acting on X-H and Y-H to form an X-Y bond |
| | | 1.21.3 | With oxygen as acceptor |
| | | 1.21.4 | With a disulfide as acceptor |
| | | 1.21.99 | With other acceptors |
| | 1.97 | Other oxidoreductases |
| | | 1.97.1 | Sole sub-subclass for oxidoreductases that do not belong in the other subclasses |
| |
| 2. | Transferases |
| | 2.1 | Transferring one-carbon groups |
| | | 2.1.1 | Methyltransferases |
| | | 2.1.2 | Hydroxymethyl-, formyl- and related transferases |
| | | 2.1.3 | Carboxy- and carbamoyltransferases |
| | | 2.1.4 | Amidinotransferases |
| | 2.2 | Transferring aldehyde or ketonic groups |
| | | 2.2.1 | Transketolases and transaldolases |
| | 2.3 | Acyltransferases |
| | | 2.3.1 | Transferring groups other than aminoacyl groups |
| | | 2.3.2 | Aminoacyltransferases |
| | | 2.3.3 | Acyl groups converted into alkyl groups on transfer |
| | 2.4 | Glycosyltransferases |
| | | 2.4.1 | Hexosyltransferases |
| | | 2.4.2 | Pentosyltransferases |
| | | 2.4.99 | Transferring other glycosyl groups |
| | 2.5 | Transferring alkyl or aryl groups, other than methyl groups |
| | | 2.5.1 | Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date) |
| | 2.6 | Transferring nitrogenous groups |
| | | 2.6.1 | Transaminases |
| | | 2.6.2 | Amidinotransferases (deleted sub-subclass) |
| | | 2.6.3 | Oximinotransferases |
| | | 2.6.99 | Transferring other nitrogenous groups |
| | 2.7 | Transferring phosphorus-containing groups |
| | | 2.7.1 | Phosphotransferases with an alcohol group as acceptor |
| | | 2.7.2 | Phosphotransferases with a carboxy group as acceptor |
| | | 2.7.3 | Phosphotransferases with a nitrogenous group as acceptor |
| | | 2.7.4 | Phosphotransferases with a phosphate group as acceptor |
| | | 2.7.5 | Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass) |
| | | 2.7.6 | Diphosphotransferases |
| | | 2.7.7 | Nucleotidyltransferases |
| | | 2.7.8 | Transferases for other substituted phosphate groups |
| | | 2.7.9 | Phosphotransferases with paired acceptors |
| | | 2.7.10 | Protein-tyrosine kinases |
| | | 2.7.11 | Protein-serine/threonine kinases |
| | | 2.7.12 | Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) |
| | | 2.7.13 | Protein-histidine kinases |
| | | 2.7.99 | Other protein kinases |
| | 2.8 | Transferring sulfur-containing groups |
| | | 2.8.1 | Sulfurtransferases |
| | | 2.8.2 | Sulfotransferases |
| | | 2.8.3 | CoA-transferases |
| | | 2.8.4 | Transferring alkylthio groups |
| | 2.9 | Transferring selenium-containing groups |
| | | 2.9.1 | Selenotransferases |
| |
| 3. | Hydrolases |
| | 3.1 | Acting on ester bonds |
| | | 3.1.1 | Carboxylic-ester hydrolases |
| | | 3.1.2 | Thioester hydrolases |
| | | 3.1.3 | Phosphoric-monoester hydrolases |
| | | 3.1.4 | Phosphoric-diester hydrolases |
| | | 3.1.5 | Triphosphoric-monoester hydrolases |
| | | 3.1.6 | Sulfuric-ester hydrolases |
| | | 3.1.7 | Diphosphoric-monoester hydrolases |
| | | 3.1.8 | Phosphoric-triester hydrolases |
| | | 3.1.11 | Exodeoxyribonucleases producing 5'-phosphomonoesters |
| | | 3.1.13 | Exoribonucleases producing 5'-phosphomonoesters |
| | | 3.1.14 | Exoribonucleases producing 3'-phosphomonoesters |
| | | 3.1.15 | Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters |
| | | 3.1.16 | Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters |
| | | 3.1.21 | Endodeoxyribonucleases producing 5'-phosphomonoesters |
| | | 3.1.22 | Endodeoxyribonucleases producing 3'-phosphomonoesters |
| | | 3.1.23 | Site-specific endodeoxyribonucleases: cleavage is sequence specific (deleted sub-subclass) |
| | | 3.1.24 | Site specific endodeoxyribonucleases: cleavage is not sequence specific (deleted sub-subclass) |
| | | 3.1.25 | Site-specific endodeoxyribonucleases that are specific for altered bases |
| | | 3.1.26 | Endoribonucleases producing 5'-phosphomonoesters |
| | | 3.1.27 | Endoribonucleases producing 3'-phosphomonoesters |
| | | 3.1.30 | Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters |
| | | 3.1.31 | Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters |
| | 3.2 | Glycosylases |
| | | 3.2.1 | Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds |
| | | 3.2.2 | Hydrolysing N-glycosyl compounds |
| | | 3.2.3 | Hydrolysing S-glycosyl compounds (deleted sub-subclass) |
| | 3.3 | Acting on ether bonds |
| | | 3.3.1 | Thioether and trialkylsulfonium hydrolases |
| | | 3.3.2 | Ether hydrolases |
| | 3.4 | Acting on peptide bonds (peptidases) |
| | | 3.4.1 | α-Amino-acyl-peptide hydrolases (deleted sub-subclass) |
| | | 3.4.2 | Peptidyl-amino-acid hydrolases (deleted sub-subclass) |
| | | 3.4.3 | Dipeptide hydrolases (deleted sub-subclass) |
| | | 3.4.4 | Peptidyl peptide hydrolases (deleted sub-subclass) |
| | | 3.4.11 | Aminopeptidases |
| | | 3.4.12 | Peptidylamino-acid hydrolases or acylamino-acid hydrolases (deleted sub-subclass) |
| | | 3.4.13 | Dipeptidases |
| | | 3.4.14 | Dipeptidyl-peptidases and tripeptidyl-peptidases |
| | | 3.4.15 | Peptidyl-dipeptidases |
| | | 3.4.16 | Serine-type carboxypeptidases |
| | | 3.4.17 | Metallocarboxypeptidases |
| | | 3.4.18 | Cysteine-type carboxypeptidases |
| | | 3.4.19 | Omega peptidases |
| | | 3.4.21 | Serine endopeptidases |
| | | 3.4.22 | Cysteine endopeptidases |
| | | 3.4.23 | Aspartic endopeptidases |
| | | 3.4.24 | Metalloendopeptidases |
| | | 3.4.25 | Threonine endopeptidases |
| | | 3.4.99 | Endopeptidases of unknown catalytic mechanism (sub-subclass is currently empty) |
| | 3.5 | Acting on carbon-nitrogen bonds, other than peptide bonds |
| | | 3.5.1 | In linear amides |
| | | 3.5.2 | In cyclic amides |
| | | 3.5.3 | In linear amidines |
| | | 3.5.4 | In cyclic amidines |
| | | 3.5.5 | In nitriles |
| | | 3.5.99 | In other compounds |
| | 3.6 | Acting on acid anhydrides |
| | | 3.6.1 | In phosphorus-containing anhydrides |
| | | 3.6.2 | In sulfonyl-containing anhydrides |
| | | 3.6.3 | Acting on acid anhydrides to catalyse transmembrane movement of substances |
| | | 3.6.4 | Acting on acid anhydrides to facilitate cellular and subcellular movement |
| | | 3.6.5 | Acting on GTP to facilitate cellular and subcellular movement |
| | 3.7 | Acting on carbon-carbon bonds |
| | | 3.7.1 | In ketonic substances |
| | 3.8 | Acting on halide bonds |
| | | 3.8.1 | In carbon-halide compounds |
| | | 3.8.2 | In phosphorus-halide compounds (deleted sub-subclass) |
| | 3.9 | Acting on phosphorus-nitrogen bonds |
| | | 3.9.1 | Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date) |
| | 3.10 | Acting on sulfur-nitrogen bonds |
| | | 3.10.1 | Acting on sulfur-nitrogen bonds (only sub-subclass identified to date) |
| | 3.11 | Acting on carbon-phosphorus bonds |
| | | 3.11.1 | Acting on carbon-phosphorus bonds (only sub-subclass identified to date) |
| | 3.12 | Acting on sulfur-sulfur bonds |
| | | 3.12.1 | Acting on sulfur-sulfur bonds (only sub-subclass identified to date) |
| | 3.13 | Acting on carbon-sulfur bonds |
| | | 3.13.1 | Acting on carbon-sulfur bonds (only sub-subclass identified to date) |
| |
| 4. | Lyases |
| | 4.1 | Carbon-carbon lyases |
| | | 4.1.1 | Carboxy-lyases |
| | | 4.1.2 | Aldehyde-lyases |
| | | 4.1.3 | Oxo-acid-lyases |
| | | 4.1.99 | Other carbon-carbon lyases |
| | 4.2 | Carbon-oxygen lyases |
| | | 4.2.1 | Hydro-lyases |
| | | 4.2.2 | Acting on polysaccharides |
| | | 4.2.3 | Acting on phosphates |
| | | 4.2.99 | Other carbon-oxygen lyases |
| | 4.3 | Carbon-nitrogen lyases |
| | | 4.3.1 | Ammonia-lyases |
| | | 4.3.2 | Amidine-lyases |
| | | 4.3.3 | Amine-lyases |
| | | 4.3.99 | Other carbon-nitrogen lyases (deleted sub-subclass) |
| | 4.4 | Carbon-sulfur lyases |
| | | 4.4.1 | Carbon-sulfur lyases (only sub-subclass identified to date) |
| | 4.5 | Carbon-halide lyases |
| | | 4.5.1 | Carbon-halide lyases (only sub-subclass identified to date) |
| | 4.6 | Phosphorus-oxygen lyases |
| | | 4.6.1 | Phosphorus-oxygen lyases (only sub-subclass identified to date) |
| | 4.99 | Other lyases |
| | | 4.99.1 | Sole sub-subclass for lyases that do not belong in the other subclasses |
| |
| 5. | Isomerases |
| | 5.1 | Racemases and epimerases |
| | | 5.1.1 | Acting on amino acids and derivatives |
| | | 5.1.2 | Acting on hydroxy acids and derivatives |
| | | 5.1.3 | Acting on carbohydrates and derivatives |
| | | 5.1.99 | Acting on other compounds |
| | 5.2 | cis-trans-Isomerases |
| | | 5.2.1 | cis-trans Isomerases (only sub-subclass identified to date) |
| | 5.3 | Intramolecular oxidoreductases |
| | | 5.3.1 | Interconverting aldoses and ketoses, and related compounds |
| | | 5.3.2 | Interconverting keto- and enol-groups |
| | | 5.3.3 | Transposing C=C bonds |
| | | 5.3.4 | Transposing S-S bonds |
| | | 5.3.99 | Other intramolecular oxidoreductases |
| | 5.4 | Intramolecular transferases |
| | | 5.4.1 | Transferring acyl groups |
| | | 5.4.2 | Phosphotransferases (phosphomutases) |
| | | 5.4.3 | Transferring amino groups |
| | | 5.4.4 | Transferring hydroxy groups |
| | | 5.4.99 | Transferring other groups |
| | 5.5 | Intramolecular lyases |
| | | 5.5.1 | Intramolecular lyases (only sub-subclass identified to date) |
| | 5.99 | Other isomerases |
| | | 5.99.1 | Sole sub-subclass for isomerases that do not belong in the other subclasses |
| |
| 6. | Ligases |
| | 6.1 | Forming carbon-oxygen bonds |
| | | 6.1.1 | Ligases forming aminoacyl-tRNA and related compounds |
| | 6.2 | Forming carbon-sulfur bonds |
| | | 6.2.1 | Acid-thiol ligases |
| | 6.3 | Forming carbon-nitrogen bonds |
| | | 6.3.1 | Acid—ammonia (or amine) ligases (amide synthases) |
| | | 6.3.2 | Acid—amino-acid ligases (peptide synthases) |
| | | 6.3.3 | Cyclo-ligases |
| | | 6.3.4 | Other carbon-nitrogen ligases |
| | | 6.3.5 | Carbon-nitrogen ligases with glutamine as amido-N-donor |
| | 6.4 | Forming carbon-carbon bonds |
| | | 6.4.1 | Ligases that form carbon-carbon bonds (only sub-subclass identified to date) |
| | 6.5 | Forming phosphoric-ester bonds |
| | | 6.5.1 | Ligases that form phosphoric-ester bonds (only sub-subclass identified to date) |
| | 6.6 | Forming nitrogen—metal bonds |
| | | 6.6.1 | Forming coordination complexes |
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